How To Use Iodine For Teeth

Information technology looks like 2020 is bringing the Canadian dental profession a gift, in the new selection of molecular iodine (I2) products from ioTech International. These products, surpass all of the existing gilded standard disinfectants. Coming out of the gate, these products appear to be game changers in antimicrobial chemistry. Dr. Gordon Christenson named ioRinse the "All-time in Class" antimicrobial agent in Clinicians Report for 2019. This technological quantum appears to have unlimited indications in medical, dental, agronomical and veterinary fields. To top it off, I2 is an essential chemical element, natural, organic and condom for chronic use and it is being priced with the nearly affordable of all the antimicrobials.

History of Iodine Use
The recorded employ of iodine in medicine, dates back to 5000 BC when seaweed and sea sponges were used to shrink goiters. Lugol's iodine was introduced in 1829, tincture of iodine in 1908 and finally povidone iodine PVP-I in 1955 (brand name: Betadine). ioTech's patented molecular iodine products first surfaced in 2017 after several years of research and development to make iodine soluble and stable in aqueous solutions (Fig. ane). Betadine has 31,600 ppm of full iodine but just 3 ppm of molecular iodine; Iotech has less than 1000 ppm of total iodine but upwardly to 600 ppm are really molecular iodine. Since information technology is ONLY the molecular iodine that is a biocidal species of iodine, all the other species in Betadine or Povidone Iodine (PVP-I) contribute to staining or toxicity merely DO Not impale microbes (Figs. 1 & 2).

Fig. ane

Fig. 2

Povidine Iodine vs. Molecular Iodine
Kickoff, let'south distinguish between PVP-I and I2 and then that we amend understand these very similar sounding, but very unlike acting, germicidal agents. PVP-I is an aqueous solution of several different species of iodine (including iodide, iodate, triiodide, hypo-iodous acrid and molecular iodine). The iodine in PVP-I is bound to a large organic molecule, polyvinylpyrrolidone which, existence highly soluble in water, carries the dissimilar iodine species, which have varying degrees of solubility, into solution along with it. x% PVP-I (common brand: Betadine) is used in hospitals, medical and dental offices worldwide. It contains over 30,000 ppm of total iodine. The iodine species nowadays in the least amount is I2 which is nowadays at but 1-three ppm1. All of the other species of iodine present contribute to staining, toxicity and irritation, but are not biocidal. Out of the over thirty,000 ppm of full iodine, the one-three ppm of I2 accounts for all of the antimicrobial activity of PVP.

ioTech International, a Florida-based antimicrobial company, has developed and patented stable aqueous formulations of I2 which contain over 100 times the available I2 (compared to PVP-I) while limiting the other non-bioactive iodine species from 30,000ppm to but a few hundred ppm (Fig. 1). This dramatically increases efficacy while drastically minimizing overall toxicity. The need for polyvinylpyrrolidone is also eliminated in these formulations. ioTech's I2 formulations are essentially articulate and do not stain compared to PVP-I, fifty-fifty at ten times the strength of PVP-I (Fig. 2).

Molecular iodine vs the gold standard antimicrobials
In comparing the efficacy of PVP-I to chlorhexidine gluconate (CHX) against six periodontal leaner (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Tannerella forsythensis, Prevotella intermedia and Streptococcus anginosus), Nakagawa, et al. determined that PVP-I reduced all bacterial strains to below detectable limits within 15 seconds. By contrast, there were more than ane,000 viable colonies remaining 60 seconds following treatment with CHX3.

ChloraPrep, a leading pre-operative surgical peel prep containing ii germicidal agents, 2.0% CHX and 70% isopropyl alcohol, required four times longer to achieve a iv.0 log kill of Aspergillus brasiliensis (a highly resilient mucus) than a 300 ppm solution of I2 alone. PVP-I was completely ineffective against Aspergillus brasiliensis after 30 minutes but the mucus was completely inactivated within 1-minute by I2. Similarly, Staph aureus was completely inactivated by an I2 conception within 30 seconds but required five minutes for PVP-I to achieve the aforementioned result.

Several studies have demonstrated the power of iodine to inactivate Strep mutans and to inhibit caries. A 25ppm I2 mouth rinse completely inactivated Rhinovirus (a resilient, not-enveloped virus largely responsible for Upper Respiratory Infections (URIs) in 30 seconds, where CHX Oral Rinse, Listerine, Scope and Colgate Total mouthwashes were completely ineffective.8 An I2 pre-procedural mouth rinse for patients is a far better option to inactivate aerosolized leaner and viruses than currently available mouthwashes. A recent report conducted at the Department of Periodontology, Tokyo Dental Schoolhouse ended that at a 30 second contact time, iodine was effective in inactivating the leaner in periodontal biofilms.9 A joint study conducted by the departments of periodontology at three European dental schools found that the persistent effect of iodine on subgingival microbial flora was far greater for iodine than for CHX (31 days vs 7 days).ten

Fig. 3

I2 is chop-chop effective confronting viruses, bacteria (both Gram negative and Gram positive), fungi and spores. In one study of hospital-level surface disinfectants, an ioTech I2 conception inactivated major pathogens responsible for Hospital Acquired Infections seven times faster than the fastest acting of 29 EPA-registered hospital disinfectants from major U.South. manufacturers. In another study, an I2 formulation inactivated a wide range of pathogens in one application within one minute that required Clorox Disinfectant Spray and Lysol Disinfectant Spray 10 minutes and multiple applications to achieve.

A key benefit of iodine formulations is that, dissimilar CHX and other antimicrobial agents, iodine does not induce resistance development in targeted microorganisms.12 The substantivity (ongoing residual upshot) of iodine for up to 72 hours is also well documented.

Molecular iodine stands up to comparison to the gilt standard of care with flying colours. Figure four shows a comparison of molecular iodine against both Betadine (PVP-one) and CHX. Notation the molecular iodine shows best because it doesn't allow for bacterial resistance, has the boldest spectrum of activity (including rhinovirus), has the most rapid speed of kill, the ability to employ it long term without staining, no calculus formation or bad taste bug. Compared to the CHX, it was the safest with no known side furnishings, not flammable like CHX, and no history of issues like affecting the microbiome adversely with chronic use, carcinogenicity, mucosal irritation, staining, altered gustatory modality sensation, occasional bacterial contamination, or rare only reported anaphylactic shock, which accept all been associated with CHX. Chlorhexidine is likewise often augmented with lxx% isopropyl alcohol to raise its bacterial efficacy which is non necessary with I2. The molecular iodine besides demonstrated the longest lasting duration of upshot.

Fig. 4

Bioscience Laboratories (Bozeman, Montana 2016-2019) did a comparison of molecular iodine (I2) to CHX oral rinse (Fig. 5). The two were compared for efficacy confronting: one) Fusobaterium nucleatum (periodontal), Streptococcus mutants (dental decay), and Rhinovirus (upper respiratory infections) and man Coronavirus. Molecular iodine came out ahead of CHX for all three cases. In fact, it was the only one that killed the Rhinovirus and it was more effective against ariogenic and periodontal bacteria, and Coronavirus, taking only fifteen seconds to completely inactivate all of these pathogens. In another BioScience Laboratories study, comparing the virucidal issue of several oral rinses, a 25 ppm I2 oral rinse completely inactivated Rhinovirus and Coronavirus in 30 seconds, where Listerine, Scope and Colgate were ineffective.

Fig. 5

Validation for the use of iodine in the dental arena
The American Heart Association, the American Dental Association and others recommend rinsing periodontal sites with povidone iodine. Professor Jorgen Slots at Herman Ostrow Dental School of Southern California has cited povidone iodine as having all the characteristics for condign a start pick in the handling and prevention of periodontal illness. With the new I2 products beingness and then much more efficacious than povidone iodine and more than efficacious and safer than Chlorhexidine Gluconate and with none of the drawbacks of either, information technology's hard to imagine that these products would not be mainstream in dental offices in the very nigh future.

Fig. half-dozen

Besides existence quickly effective against periodontal and cariogenic pathogens, molecular iodine penetrates oral biofilms and it destroys bacteria that produce volatile sulfur compounds, making information technology a great product for halitosis too. Reports show that an increase in the concentration of the molecular iodine used will outcome in a corresponding greater biocidal activeness, allowing for titration of the concentration depending on the need (Fig. 7).

Fig. 7

Suggested indications for use of molecular iodine in dentistry
Periodontal illness (affects 75-80% of developed population), molar decay (affects 96% of Americans), all topically treated oral infections such as fungal, viral or bacterial, oral mucositis, thrush, canker sores, herpetic ulcers, pre and post procedural rinses, in-part subgingival irrigation, and daily at-home use, including utilise in units such equally water irrigation devices or tray awarding as a gel. Caries management protocols might include I2 and a combination of xylitol/erythrotol (25%) with I2 is showing hope; endodontic indications are as an end irrigant, file lubricant, ultrasonic culvert solution, antimicrobial sealer+++. A second commodity will follow with indications and methods of utilize of I2 in the dental office.

Molecular iodine's new breakthrough applied science advantages
Other products are contra-indicated for chronic utilise. Molecular iodine is an essential nutrient and is safe for chronic employ. It is used in very low concentrations and is strongly effective against bacteria, fungi, viruses and even spores. This product is articulate and non-staining. Information technology is more effective and safer than chlorhexidine gluconate, povidone iodine, peroxide, booze or whatever other currently bachelor mouth rinse. It is the most effective and efficient product at reducing both periodontal and cariogenic pathogens without inducing microbial resistance. This production is natural and organic and can be delivered for abode use, then chair time is not required to care for with it. Other advantages include:

Broad spectrum of kill
Rapid speed of impale
Lack of microbial resistance
Excellent safe and allergy profile
Substantivity
Ease of apply
Affordable to patients
No deleterious side effects
Indicated for chronic use

Three oral care products are now being marketed to the dental profession. A concentrated aqueous solution, a ready to use aqueous solution and a gel (Fig. viii).

Fig. 8

Any inquiries nigh the products or for buy can exist fabricated by contacting ioTech International, https://iotechinternational.com. One assuming periodontist from Baltimore Dental, who beta tested ioTech rinses in his office has suggested that, "ioTech products will likely be as therapeutic as scaling and root planing in the treatment and direction of periodontal disease". This is hard to imagine just if nosotros can control the biofilm and microflora intraorally in a safety fashion, we solve the majority of microbial oral diseases, peculiarly related to periodontal and carious pathology.

This rubber, effective, natural and organic antimicrobial is showing existent promise to becoming the chemotherapeutic/preventative amanuensis of choice in the dental profession. We wait forward to further research and validation of new I2 products in the time to come.

Oral Health welcomes this original article.

Disclaimer: Dr. Herb Moskowitz is the Chairman and Co-Founder of ioTech International and Co-Writer of ioTech's patents; Dr. Janice Goodman has a financial interest in the company beingness profiled.

About the Writer

Herb Moskowitz has 40 years of healthcare feel, including 25 years in the clinical practice of dentistry. He tin be reached at herbmoskowitz@iotechinternational.com.

Janice Goodman practices general dentistry in downtown Toronto and is a member of the Editorial Board of Oral Health Dental Journal. She tin can be reached at dentistryinto@gmail.com.